The strikes took place in Yemen's southern Shabwa province, according to the Xinhua news agency.
The drone strike hit several militant hideouts, training facilities and arsenals in the insurgent-controlled town of Azzan, around 150 kilometres east of Ataq, the provincial capital of Shabwa, the report said.
Among the dead are "foreign jihadist leaders," from Syria and Algeria, the report said, citing unnamed security officials.
The Yemeni Defence Ministry on Monday said at least 11 militants were killed in a drone strike on Saturday.
The United States is increasingly depending on unmanned armed aircraft to target militants.